Scientists develop real-time imaging for brain drug uptake in Australia-Xinhua

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  • Scientists develop real-time imaging for brain drug uptake in Australia

    Source: Xinhua

    Editor: huaxia

    2025-07-11 16:58:15

    SYDNEY, July 11 (Xinhua) -- Scientists in Australia have developed an innovative device that integrates ultrasound and advanced imaging to enhance the safe delivery of drugs into the brain.

    The technology could transform treatments of neurodegenerative diseases such as Alzheimer's and Parkinson's, where effective drug delivery to targeted brain regions remains a major challenge, said researchers at Australia's University of Queensland (UQ).

    The technology allows real-time imaging of brain cells after ultrasound, enabling targeted drug delivery across the blood-brain barrier to allow researchers to identify and map changes in treated cells and observe how they respond and recover, according to a UQ statement released on Friday.

    The blood-brain barrier blocks most drugs from entering the brain, but the device uses sonoporation -- ultrasound-activated microbubbles -- to briefly open tiny pores, allowing drug delivery to brain tissue, said the study's lead author Pranesh Padmanabhan.

    "The goal is really to improve the rate of uptake of drugs into the brain, as currently only about 1-2 percent of small molecule drugs actually reach it," said Padmanabhan from UQ's School of Biomedical Sciences and Queensland Brain Institute.

    The custom-built system, developed over five years, enables scientists to track cellular changes at the single-cell and molecule level after ultrasound, providing insights to optimize protocols for safer and more effective drug delivery to the brain, said the study published in the Journal of Controlled Release.

    Beyond neurology, the technology could offer new possibilities for sonoporation-based therapies in fields like cardiology and oncology, researchers said.